Dr Christopher Lawson
Research Associate
Strathclyde Institute of Pharmacy and Biomedical Sciences
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Publications
- IL-1β stimulates a novel axis within the NFκB pathway in endothelial cells regulated by IKKα and TAK-1
- Craig Rachel, McIntosh Kathryn, Ho Ka Ho, McCulloch Ashley, Riley Christopher, Lawson Christopher, MacKay Simon P, Paul Andrew, Coats Paul, Plevin Robin
- Biochemical Pharmacology Vol 232 (2025)
- https://doi.org/10.1016/j.bcp.2024.116736
- The activities of suaveolol and other compounds from hyptis suaveolens and momordica charantia against the aetiological agents of African trypanosomiasis, leishmaniasis and malaria
- Oaikhena Enimie E, Yahaya Umar A, Abdulsalami Sani M, Egbe Nkechi L, Adeyemi Modupe M, Ungogo Marzuq A, Ebiloma Godwin U, Zoiku Felix K, Fordjour Prince A, Elati Hamza AA, Quashie Neils B, Igoli John O, Gray Alexander I, Lawson Christopher, Ferro Valerie A, de Koning Harry P
- Experimental Parasitology Vol 263-264 (2024)
- https://doi.org/10.1016/j.exppara.2024.108807
- Design and synthesis of novel aminoindazole-pyrrolo[2,3-b]pyridine inhibitors of IKKα that selectively perturb cellular non-canonical NF-κB signalling
- Riley Christopher, Ammar Usama, Alsfouk Aisha, Anthony Nahoum G, Baiget Jessica, Berretta Giacomo, Breen David, Huggan Judith, Lawson Christopher, McIntosh Kathryn, Plevin Robin, Suckling Colin J, Young Louise C, Paul Andrew, Mackay Simon P
- Molecules Vol 29 (2024)
- https://doi.org/10.3390/molecules29153515
- IL-1β stimulates a novel, IKKα -dependent, NIK -independent activation of non-canonical NFκB signalling
- McIntosh Kathryn, Khalaf Yousif H, Craig Rachel, West Christopher, McCulloch Ashley, Waghmare Ajay, Lawson Christopher, Chan Edmond YW, MacKay Simon, Paul Andrew, Plevin Robin
- Cellular Signalling Vol 107 (2023)
- https://doi.org/10.1016/j.cellsig.2023.110684
- Fatty acid metabolism of Mycobacterium tuberculosis : a double-edged sword
- Quinonez Camila G, Lee Jae Jin, Lim Juhyeon, Odell Mark, Lawson Christopher P, Anyogu Amarachukwu, Raheem Saki, Eoh Hyungjin
- Microbial Cell Vol 9, pp. 123-125 (2022)
- https://doi.org/10.15698/mic2022.05.777
- The role of fatty acid metabolism in drug tolerance of Mycobacterium tuberculosis
- Quinonez Camila G, Lee Jae Jin, Lim Juhyeon, Odell Mark, Lawson Christopher P, Anyogu Amararachukwu, Raheem Saki, Eoh Hyungjin
- mBio Vol 13 (2022)
- https://doi.org/10.1128/mbio.03559-21
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Projects
- Fluorescent Drugs for Difficult Bugs: Engineering Fluorescent Antibiotics to Track Antibiotic Uptake and Resistance in Chronic Bacterial Infections.
- Rooney, Liam (Principal Investigator) Lawson, Christopher (Co-investigator)
- One of the greatest biomedical challenges is overcoming difficult-to-treat chronic infections while minimising and improving antibiotic usage. This extends to improving drug delivery and therapeutics for biofilms. The discovery of biofilm nutrient transport channels changed our understanding of how biofilms acquire external resources. Meanwhile, we developed a streamlined manufacturing method for bespoke fluorescent drug labelling. Our collaboration maximises our expertise by producing fluorescent antibiotics, tracking their uptake through biofilm channels, quantifying their dispersion, and measuring their efficacy.
This research presents a step change in measuring antibiotic activity and will provide evidence of channel-mediated drug uptake. This research informs better use of antibiotics to combat antimicrobial resistance (AMR), has multiple beneficiaries owing to the new methods and understanding of drug uptake, and maximises impact by informing the development of channel-targeting antibiotic delivery strategies for wound healing. - 02-Jan-2023 - 02-Jan-2024
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Contact
Dr
Christopher
Lawson
Research Associate
Strathclyde Institute of Pharmacy and Biomedical Sciences
Email: christopher.lawson@strath.ac.uk
Tel: 01415483347